7161664
Tocris Bioscience™ PSEM 89S
PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Manufacturer: Fischer Scientific
CAS Number: 1336913-03-1
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Chemical Name or Material
N-(3 S)-1-Azabicyclo[2.2.2 ]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Target
Pharmacologically Selective Effector Molecules/PSEM
Formula Weight
404.38
CAS
1336913-03-1
Molecular Formula
C16H22N2O3.CF3CO2H
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ PSEM 89S | -- | ₹ 82,458.50 | ||
Tocris Bioscience™ PSEM 89S | -- | ₹ 21,449.00 | ||
Medchemexpress LLC HY-112217A 5mg Medchemexpress, PSEM 89S (TFA) CAS:1336913-03-1 Purity:>98% | -- | ₹ 11,214.00 | ||
1336913-03-1 | N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamidetrifluoroacetate | -- | ₹ 1,869.00 - ₹ 47,971.00 |
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Description
- PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively)
- Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro
- Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo , leading to suppression of feeding
- Brain penetrant
- Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C