7166782
Tocris™ A 317491 sodium salt
Selective, high affinity P2X3 and P2X2/3 antagonist; antinociceptive
Manufacturer: Fischer Scientific
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Chemical Name or Material
5-[[[(3-Phenoxyphenyl)methyl][(1 S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid disodium salt
Molecular Formula
C33H25NO8Na2
Product Type
Antagonist
Target
P2X Receptor Antagonists
Formula Weight
609.54
Purity
98%
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Description
- Selective, high affinity non-nucleotide P2X3 and P2X2/3 receptor antagonist (Ki values are 9, 22, 22 and 92 nM at human P2X2/3, rat P2X3, human P2X3 and rat P2X2/3, respectively); blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22 - 92 nM)
- Exhibits selectivity over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes (IC50 > 5 μM)
- Reduces mechanical allodynia and thermal hyperalgesia in the CCI in vivo models
- Antinociceptive.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C