7182930
Tocris Bioscience™ OptoBI-1
Photoswitchable TRPC3/6/7 agonist
Manufacturer: Fischer Scientific
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Chemical Name or Material
1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one
Molecular Formula
C32H37N5O2
Purity
98%
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Description
- Description OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis -form ∽0.1 μM at TRPC3)
- Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm
- Returns to trans conformation in the dark after ∽ 50 minutes
- No effect observed on TRPC4 or 5
- Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis -state.