7112428

Tocris Bioscience™ Bosentan

High affinity dual ETA and ETB receptor antagonist;orally bioavailable

Manufacturer: Fischer Scientific

CAS Number: 147536-97-8

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Product Type

Antagonist

CAS

147536-97-8

Formula Weight

551.61g/mol

For Use With (Application)

Non-selective Endothelin Receptor Antagonists

Target Proteins

Non-selective Endothelin Receptor

Molecular Formula

C27H29N5O6S

Content And Storage

Store at 4°C

Other Options

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Description

  • High affinity dual ETA and ETB receptor antagonist (Ki values are 4.7 and 95 nM for ETA and ETB, respectively)
  • Inhibits ET-1 induced contraction of isolated rat aorta and sarafotoxin S6C-induced contraction of rat trachea in vitro
  • Orally bioavailable.