7112437
Tocris Bioscience™ AZ 10397767
Potent CXCR2 antagonist
Manufacturer: Fischer Scientific
CAS Number: 333742-63-5
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Product Type
Antagonist
CAS
333742-63-5
Formula Weight
400.88g/mol
For Use With (Application)
Chemokine Receptor Antagonists
Target Proteins
Chemokine Receptor
Molecular Formula
C15H14ClFN4O2S2
Content And Storage
Store at -20°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
Tocris Bioscience™ AZ 10397767 | -- | ₹ 30,146.08 | ||
Tocris Bioscience™ AZ 10397767 | -- | ₹ 1,26,675.48 | ||
333742-63-5 | 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one | -- | -- |
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Description
- Potent CXCR2 antagonist (IC50 = 1 nM); attenuates oxaliplatin -induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells
- Reduces the numbers of neutrophils infiltrating into tumors in both in vitro and in vivo models and delayed tumor growth
- Orally bioavailable.