01-674-163
AIF Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 01-674-163-Each-of-1 | In Stock | ₹ 46,814.00 |
01-674-163 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,814.00
GST (18%): ₹ 8,426.52
Total Price: ₹ 55,240.52
Antigen
AIF
Classification
Polyclonal
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
O95831
Gene Symbols
AIFM1
Immunogen
Synthetic peptide corresponding to residues 109-122 of human AIF.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Conjugate
Unconjugated
Gene
AIFM1
Gene Alias
Apoptosis-inducing factor 1 mitochondrial, Apoptosis-inducing factor 1, PDCD8
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9131
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
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Description
- A suggested positive control for this product is K562 cell lysate
- Apoptosis Inducing Factor (AIF) causes chromatin condensation and DNA fragmentation
- AIF was recently identified, and cloned
- Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation
- These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins
- Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria
- AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9
- AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli
- AIF is highly conserved between human and mouse and widely expressed
- Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy
- Alternative splicing results in multiple transcript variants of AIF and a related pseudogene has been identified on chromosome 10.