TIMP1 Monoclonal Antibody (C8), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TIMP1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
CLGI, collagenase inhibitor, Collagenase inhibitor 16C8 fibroblast, EG-1, Embryogenin-1, EPA, EPO, erythroid potentiating activity, erythroid-potentiating activity, Fibroblast collagenase inhibitor, FLJ90373, HCI, Metalloproteinase inhibitor, metalloproteinase inhibitor 1, metalloproteinase tissue inhibitor, metalloproteinase tissue inhibitor 1, MMP inhibitor, RP1-230G1.3, Timp, TIMP 1, TIMP metallopeptidase inhibitor 1, TIMP1, TIMP-1, TIMP-1 protein, tissue inhibitor of matrix metalloproteinase-1, tissue inhibitor of metal proteinases, tissue inhibitor of metallopeptidase 1, tissue inhibitor of metalloproteinase, tissue inhibitor of metalloproteinase 1, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor), tissue inhibitor of metalloproteinase-1, tissue inhibitor of metalloproteinases, tissue inhibitor of metalloproteinases 1, TPA-induced protein, TPA-S1
Gene Symbols
TIMP1
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
TIMP1
Clone
C8
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Mouse, Rat
Gene Accession No.
P12032, P30120
Gene ID (Entrez)
116510, 21857
Immunogen
Recombinant Rat TIMP1 protein, Cys24-Ala217 (Accession #P30120)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor
- TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16
- It also functions as a growth factor that regulates cell differenation, migration, and cell death
- TIMP1 activates cellular signaling cascades via CD63 and ITGB1.