PAI1 Monoclonal Antibody (D1), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
PAI1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
Endothelial plasminogen activator inhibitor, nexin, plasminogen activator inhibitor type 1, PAI, PAI1, PAI-1, PAI1 protein, PAI1A, Pai1aa, Planh, Planh1, plas, plasminogen activator inhibitor, plasminogen activator inhibitor 1, plasminogen activator inhibitor I, plasminogen activator inhibitor, type I, plasminogen activator inhibitor-1, Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI), putative plasminogen activator inhibitor-1, RATPAI1A, serine (or cysteine) peptidase inhibitor, clade E, member 1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, serine (or cysteine) proteinase inhibitor, clade E, member 1, serine (or cysteine) proteinase inhibitor, member 1, serpin E1, serpin family E member 1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, SERPINE1, SERPINE-1
Gene Symbols
Serpine1
Isotype
IgG1 κ
Purification Method
Protein A/G
Gene
Serpine1
Clone
D1
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Porcine
Gene Accession No.
P05121, P79335
Gene ID (Entrez)
396945, 5054
Immunogen
Recombinant Human PAI1 protein, Val24-Pro402 (Accession #P05121)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Related Products
Description
- PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA)
- Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells
- Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors
- PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome
- Defects in PAI-1 are characterized by abnormal bleeding
- PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival
- Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency)
- Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.