Cofilin Monoclonal Antibody (C12), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Cofilin
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% Proclin 300, pH 7.4
Gene Alias
18 kDa phosphoprotein, AA959946, CFL, Cfl1, CFL-1, Cof, COF1, cofilin, cofilin 1, cofilin 1 (non-muscle), cofilin 1, non-muscle, cofilin, non-muscle isoform, Cofilin1, Cofilin-1, cofilin-1-like protein, epididymis secretory protein Li 15, HEL-S-15, n-cofilin, p18
Gene Symbols
CFL1
Isotype
IgG2a κ
Purification Method
Protein A/G
Gene
CFL1
Clone
C12
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Bovine, Human, Porcine
Gene Accession No.
P10668, P23528, Q5E9F7
Gene ID (Entrez)
1072, 445532, 534553
Immunogen
Recombinant Human CFL1 protein, Ser3-Leu161 (Accession #P23528)
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
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Description
- Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity
- Regulates actin cytoskeleton dynamics
- Important for normal progress through mitosis and normal cytokinesis
- Plays a role in the regulation of cell morphology and cytoskeletal organization
- Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation
- Required for neural tube morphogenesis and neural crest cell migration.