Drp1 (Density Regulated Protein-1) Mouse, Unlabeled, Clone: 22, BD

Description

• In culture, cell density can have profound effects on gene expression, enzymatic activity, and cell signaling pathways
• Using differential screening of cDNAs from low-passage nontumorigenic teratocarcinoma cells versus high passage tumorigenic cells, a protein was identified that is regulated in cell-density dependent manner
• This protein, density-regulated protein 1 (drp1), contains putative sites for N-myristoylation and phosphorylation sites for cAMP and/or cGMP-dependent kinase, casein kinase II, and PKC
• The expression of drp1 is enriched in high density cultures of both nontumorigenic and tumorigenic cell lines and is widely detected in adult organs, especially skeletal and cardiac muscle
• In addition, increased expression of drp1 is not due to growth arrest as a result of serum starvation or TGF-β treatment nor is it a result of factors found in the media of high density cultures
• Interestingly, drp1 is expressed highest in skeletal and cardiac muscle where unique cell-cell contacts are involved in muscle cell membrane depolarization and contraction
• Thus, drp1 expression may be regulated by signaling pathways related to specific types of cell-cell contacts
• Host Species: Mouse Clone: 22 Isotype: IgG2a Species Reactivity [for Features Main]: Human Immunogen: Human Drp1 aa
• 19-201 Immunofluorescence, Western Blotting