4544902
Epredia™ Lab Vision™ CD8 Ab-1, Mouse Monoclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ CD8 Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Fischer Scientific
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Antigen
CD8 Ab-1
Classification
Monoclonal
Host Species
Mouse
Research Discipline
T-Cell
Immunogen
A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of alpha chain of human CD8 molecule
Clone
C8/144B
Conjugate
Unconjugated
Regulatory Status
IVD
Target Species
Human
Primary or Secondary
Primary
Related Products
Description
- CD8 molecule consists of two chains, termed α and Β chain, which are expressed as a disulphide-α β heterdimer or as an alpha α homodimer on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells
- The majority of CD8+ Tcells expresses CD8 as αβheterodimer
- CD8 functions as a coreceptor in concert with TCR for binding the MHC class I/peptide complex
- The HIV-2 envelope glycoprotein binds CD8 α chain (but not Β chain)
- Host Species: Mouse Clone: C8/144B Isotype: IgG1/κ Species Reactivity: Human
- Does not react with rat
- Others not known
- Epitope: C-terminal Immunogen: A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of α-chain of human CD8 molecule Molecular Weight: 32 kDa Positive Control: Lymph node or tonsil Cellular Localization: Membrane Recommended for: Immunohistochemistry (Formalin/paraffin) General References: 1
- Mason DY, et
- al
- Journal of Clinical Pathology, 1992, 45(12):1084-8.