Bax Monoclonal Antibody (1D1), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-135-85-Each-of-1 | In Stock | ₹ 24,030.00 |
50-135-85 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,030.00
GST (18%): ₹ 4,325.40
Total Price: ₹ 28,355.40
Antigen
Bax
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
Q63690
Gene Symbols
BAX
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
24887
Content And Storage
4° C
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Clone
1D1
Conjugate
Unconjugated
Gene
BAX
Gene Alias
apoptosis regulator BAX; Apoptosis regulator Bcl-X; Bax; Bax zeta; BAX-ALPHA; Bax-alpha protein; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2 associated X, apoptosis regulator; BCL2 like 1; BCL2-associated protein; Bcl-2-associated protein Bax; Bcl2-associated protein Bax; Bcl-2-associated X protein; BCL2-associated X protein; BCL2-associated X protein omega; BCL2L; BCL2L1; Bcl2-L-1; BCL2L4; Bcl2-L-4; BCL2-like 1; bcl-2-like protein 1; Bcl-2-like protein 4; BCLX; Bcl-X; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
Host Species
Mouse
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG1 κ
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Description
- Description: The 1D1 monoclonal antibody reacts with rat Bax (∽21 kDa), and does not react with human and mouse Bax
- 1D1 shows no cross-reaction with Bcl-2 or Bcl-xL proteins
- Bcl-2, Bax, and Bcl-xL are members of a protein family that regulates apoptosis; while several family members including Bcl-2 and Bcl-xL inhibit apoptosis, overexpression of Bax promotes programmed cell death
- A rat Bax protein peptide sequence, aa 3-16, was used as immunogen
- Applications Reported: The 1D1 antibody has been reported for use in immunoprecipitation, and immunoblotting (WB)
- Applications Tested: The 1D1 antibody has been tested by Western Blot and can be used at approximately 1 μg/mL
- 1D1 can also be used in IP at approximately 1-10 μg/mL
- It is recommended that the reagent be carefully titrated for optimal performance in the assay of interest
- Purity: Greater than 90%, as determined by SDS-PAGE
- Aggregation: Less than 10%, as determined by HPLC
- Filtration: 0.2 μm post-manufacturing filtered
- BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis
- Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function
- Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2
- The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain
- Bcl-2 is also expressed in different Isoforms
- Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha
- Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa)
- BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis
- Overexpression of BAX functions to promote cell death
- BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.