50-173-6923
TAZ Mouse anti-Human, Mouse, Rat, Clone: 2A12A10, Proteintech
Manufacturer: Proteintech Group Inc
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-173-6923-Each-of-1 | In Stock | ₹ 44,150.23 |
50-173-6923 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,150.23
GST (18%): ₹ 7,947.041
Total Price: ₹ 52,097.271
Antigen
TAZ
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene Accession No.
Q9EPK5, Q9GZV5
Gene Symbols
Wwtr1
Immunogen
TAZ Fusion Protein Ag13330
Quantity
150 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
2A12A10
Conjugate
Unconjugated
Gene
WWTR1
Gene Alias
TAZ, WWTR1
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
25937, 295062, 97064
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis
- The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1
- In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ
- WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation
- WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex
- WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.