50-194-3848
DNMT3LRabbit anti-Human, Polyclonal, Rockland™
Manufacturer: Rockland Immunochemicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-194-3848-Each-of-1 | In Stock | ₹ 52,930.08 |
50-194-3848 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,930.08
GST (18%): ₹ 9,527.414
Total Price: ₹ 62,457.494
Antigen
DNMT3L
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DNMT3L
Gene Alias
cytosine-5-methyltransferase 3-like protein; D6Ertd14e; DNA (cytosine-5-)-methyltransferase 3-like; DNA (cytosine-5)-methyltransferase 3-like; DNA methyltransferase 3 like; Dnmt 3L; DNMT3L; ecat7; human cytosine-5-methyltransferase 3-like protein; MGC1090
Host Species
Rabbit
Regulatory Status
RUO
Gene ID (Entrez)
29947
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration
1.11 mg/mL
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Accession No.
Q9UJW3
Gene Symbols
DNMT3L
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody is expected to cross-react with mouse as the sequence of the human immunogen shows 76% identity with mouse
- Reactivity with DNMT3L from other species has not yet been tested
- Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and development
- Three families of mammalian DNA methyltransferases have been identified: DNMT1, DNMT2, and DNMT3
- DNMT1 is constitutively expressed in proliferating cells and functions as a maintenance methyltransferase, transferring proper methylation patterns to newly synthesized DNA during replication
- DNMT3A and DNMT3B are strongly expressed in embryonic stem cells with reduced expression in adult somatic tissues
- DNMT3A and DNMT3B function as de novo methyltransferases that methylate previously unmethylated regions of DNA
- DNMT2 is expressed at low levels in adult somatic tissues and its inactivation affects neither de novo nor maintenance DNA methylation
- DNMT3L is a catalytically inactive regulatory factor for the DNMT3A and DNMT3B de novo methyltransferases that is expressed at low levels in embryonic stem cells, testis, ovaries, and thymus
- These de novo methyltransferases consist of a heterotetrameric complex containing two molecules of DNMT3L, and either two molecules of DNMT3A or DNMT3B
- DNMT3L contains an amino-terminal ATRX-DNMT3-DNMT3L (ADD) domain and a carboxy-terminal methyltransferase-like domain.