5349381
MilliporeSigma™ anti-CD45, PE-Cy7, Clone: 30-F11,
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD45
Applications
Flow Cytometry
Conjugate
PE-Cyanine7
Host Species
Rat
Research Discipline
Inflammation, Immunology
Formulation
Purified Rat monoclonal containing 10mM NaH2PO4, 150mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2.
Gene Symbols
Ptprc, Ly-5
Isotype
IgG2b κ
Purification Method
Purified by size-exclusion chromatography
Clone
30-F11
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Accession No.
P06800
Immunogen
Proprietary immunogen
Primary or Secondary
Primary
Content And Storage
2°C to 8°C undiluted for one year from date of shipment protected from light; Do not freeze
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Description
- Specifically detects CD45 Clone: 30-F11 in Mouse samples, and it is validated for Flow Cytometry The 30-F11 antibody reacts with mouse CD45, which is one of the most abundant hematopoietic markers and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA)
- CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns
- With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor
- Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others
- The 30-F11 antibody is widely used as a leukocyte marker for B cells, T cell subsets and NK cell subsets.