Blimp-1 Monoclonal Antibody (6D3), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Blimp-1
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Alias
B lymphocyte-induced maturation protein 1; b2b1765Clo; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; Blimp1; BLIMP-1; B-lymphocyte-induced maturation protein 1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PR/SET domain 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; Prdm1; RP1-134E15.1; ZNFPR1A1
Gene Symbols
PRDM1
Primary or Secondary
Primary
Content And Storage
4° C
Gene
PRDM1
Clone
6D3
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Rat
Target Species
Human, Mouse
Gene Accession No.
O75626, Q60636
Gene ID (Entrez)
12142, 639
Isotype
IgG2a
Purification Method
Affinity chromatography
Product Type
Antibody
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Description
- Description: This 6D3 monoclonal antibody reacts with B lymphocyte-induced maturation protein-1 (Blimp-1), a transcriptional repressor expressed in B and T cells
- This approximately 90-kDa protein contains five consecutive Kruppel-like zinc finger domains by which it binds DNA
- In B cells, Blimp-1 promotes terminal differentiation into antibody-secreting plasma cells during a primary immune response
- In addition, Blimp-1 has been implicated in germinal center formation in response to T-dependent and T-independent antigens, as well as in some diffuse large B cell lymphomas
- Expressed in CD4+ and CD8+ effector/memory T cells and FoxP3+ regulatory T cells, reports have suggested possible roles for Blimp-1 in T cell homeostasis and suppression of IL-2 production
- Moreover, by suppressing Th1 differentiation, Blimp-1 plays a role in T helper cell differentiation
- Finally, Blimp-1 has been demonstrated to play a significant role in the terminal differentiation of effector and effector memory CD8+ T cells during viral infection
- Applications Reported: This 6D3 antibody has been reported for use in immunoblotting (WB) and immunohistology staining of paraffin-embedded tissue sections
- Applications Tested: This 6D3 antibody has been tested by western blot of reduced A20 cell lysates
- For western blottiing, this antibody can be used at 1-10 μg/mL
- Moreover, this antibody was tested by immunohistochemistry of formalin-fixed paraffin embedded human tonsil tissue
- Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus
- It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages
- Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells
- It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.