7144163
ATRX Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
ATRX
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
RP5-875J14.1, ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, ATP-dependent helicase ATRX, DNA dependent ATPase and helicase, RAD54 homolog, X-linked helicase II, X-linked nuclear protein, Zinc finger helicase, alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae), helicase 2, X-linked, transcriptional regulator ATRX
Gene Symbols
ATRX
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P46100
Gene ID (Entrez)
546
Immunogen
Between 2442 and C-term
Primary or Secondary
Primary
Content And Storage
4° C
Gene
ATRX
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Lit The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins
- The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome
- These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes
- This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis
- Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.