Aurora B Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Aurora B
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
O70126, Q96GD4
Gene ID (Entrez)
20877, 9212
Immunogen
This Aurora B antibody was raised against a peptide including the C-terminus of human Aurora B.
Primary or Secondary
Primary
Product Type
Antibody
Concentration
Conc. Not Determined
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias
AIE2; AIK1; Aik2; AIK3; AIM1; AIM-1; AIRK2; AIRK3; AL022959; Ark2; ARK-2; ARK3; ARK-3; AurB; Aurkb; aurkb-sv1; aurkb-sv2; AURKC; Aurora 1; Aurora 3; Aurora- and IPL1-like midbody-associated protein 1; aurora B; Aurora kinase B; aurora kinase B; serine/threonine-protein kinase 12; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora kinase C; Aurora/IPL1-related kinase 2; aurora-1; aurora-B; aurora-related kinase 2; BOS_18918; EC 2.7.11.1; IPL1; NP_004208; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 5; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK1; STK-1; STK12; STK13; STK5
Gene Symbols
AURKB
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
AURKB
Related Products
Description
- Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC)
- This complex functions in chromosome alignment and separation, histone modification, and cytokinesis
- CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB
- Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB
- Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3
- AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples
- Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.