Progerin Monoclonal Antibody (13A4), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Progerin
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32
Gene Symbols
LMNA
Isotype
IgG1 κ
Purification Method
Protein G
Product Type
Antibody
Clone
13A4
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P02545
Gene ID (Entrez)
4000
Immunogen
This Progerin antibody was raised against a peptide corresponding to amino acids 604-611 of human Progerin.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
LMNA
Related Products
Description
- Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome
- Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin-A/C
- This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acid internal deletion within the C-terminal domain of the protein
- Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of the LMNA gene.