7188596
Histone H3K27me2me3 Monoclonal Antibody (7B11), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Histone H3K27me2me3
Concentration
Conc. Not Determined
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
ascites with 30% glycerol and 0.035% sodium azide; pH
Gene ID (Entrez)
15078, 15081
Immunogen
This Histone H3 di/trimethyl Lys27 antibody was raised against a peptide including trimethyl-lysine 27 of histone H3.
Primary or Secondary
Primary
Product Type
Antibody
Clone
7B11
Applications
ChIP Assay, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse
Gene Accession No.
P84244
Gene Symbols
H3F3A, H3F3B
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
H3F3B
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Description
- Description Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells
- H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome
- Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability
- Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors
- The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes
- These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.