SREBP-1 Monoclonal Antibody (IgG-2A4), Active Motif™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
SREBP-1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
ADD1; ADD-1; Adipocyte determination- and differentiation-dependent factor 1; BHLHD1; Class D basic helix-loop-helix protein 1; D630008H06; I79_010155; nt-SREBP1; Processed sterol regulatory element-binding protein 1; SREBF1; SREBP1; SREBP-1; SREBP1a; SREBP-1a; SREBP1c; SREBP-1c; sterol regulatory element binding protein 1; sterol regulatory element binding protein-1; sterol regulatory element binding transcription factor 1; sterol regulatory element binding-protein 1; Sterol regulatory element-binding protein 1; Sterol regulatory element-binding transcription factor 1
Gene Symbols
SREBF1
Isotype
IgG
Purification Method
Protein G
Product Type
Antibody
Clone
IgG-2A4
Applications
ChIP Assay, Gel Shift, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
P36956
Gene ID (Entrez)
6720
Immunogen
This SREBP-1 antibody was raised against a recombinant protein corresponding to amino acids 301-407 of human SREBP-1.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
SREBF1
Related Products
Description
- Sterol regulatory element-binding proteins (SREBPs) are transcription factors that are members of the basic helix-loop-helix leucine zipper family of DNA binding proteins
- Three isoforms have been identified in mammalian tissues that vary in structure, regulation, and function
- SREBP-1a and SREBP-1c (originally cloned as ADD1) are protein products of alternative promoter usage of the SREBP-1 gene
- The third isoform is transcribed from a different gene, SREBP-2
- SREBPs are present as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane
- Upon activation, the SREBP protein is translocated to the Golgi and proteolytic cleavage occurs resulting in a mature transcriptionally active 60-78 kDa fragment
- In liver and adipose tissues, SREBPs have a significant influence on lipid and cholesterol accumulation by inducing the transcription of genes involved in these processes
- While SREBP-1 is thought to be more important in regulating the expression of genes involved in triglyceride synthesis and accumulation, SREBP-2 has been more closely linked to those involved in cholesterol synthesis and accumulation.