CDKN2A (phospho S152) Rabbit anti-Human, Polyclonal , Abnova™
Manufacturer: Abnova Corporation
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 89-956-742-Each-of-1 | In Stock | ₹ 55,803.00 |
89-956-742 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,803.00
GST (18%): ₹ 10,044.54
Total Price: ₹ 65,847.54
Antigen
CDKN2A (phospho S152)
Classification
Polyclonal
Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human CDKN2A.
Formulation
In PBS (without Mg2+and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene Symbols
CDKN2A
Immunogen
A synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S152 of human CDKN2A.
Quantity
100 μL
Primary or Secondary
Primary
Test Specificity
CDKN2A (phospho S152) polyclonal antibody detects endogenous levels of human CDKN2A only when phosphorylated at serine 152.
Content And Storage
Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Isotype
IgG
Applications
Immunohistochemistry (PFA fixed), Western Blot
Conjugate
Unconjugated
Dilution
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100) Western Blot (1:500-1:3000) The optimal working dilution should be determined by the end user.
Gene Alias
ARF/CDK4I/CDKN2/CMM2/INK4/INK4a/MLM/MTS1/TP16/p14/p14ARF/p16/p16INK4/p16INK4a/p19
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1029
Target Species
Human
Form
Liquid
Related Products
Description
- This gene generates several transcript variants which differ in their first exons
- At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase
- The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants
- This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53
- In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control
- This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene
- [provided by RefSeq]