ABC488MI
MilliporeSigma™ Rabbit anti-Gumby, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABC488MI-Each-of-1 | In Stock | ₹ 42,968.31 |
ABC488MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
Gumby
Classification
Polyclonal
Gene Accession No.
Q96BN8
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Western Blot
Formulation
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
OTULIN; FAM105B
Immunogen
GST-tagged recombinant protein corresponding to human Gumby.
Quantity
100 μL
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_612357
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Related Products
Description
- Specifically detects Gumby in Human samples, and it is validated for Western Blotting Ubiquitin thioesterase otulin (EC:3.4.19.12; UniProt Q96BN8), also known as Deubiquitinating enzyme otulin, Gumby, OTU domain-containing deubiquitinase with linear linkage specificity, Protein FAM105B, Ubiquitin thioesterase Gumby), is encoded by the OTULIN gene in murine species
- Gumby belongs to the ovarian tumour (OTU) domain-containing protease family of deubiquitinases (DUBs) that catalyze the removal of ubiquitins from ubiquitinated proteins
- Gumby is reported to associate with linear ubiquitin assembly complex (LUBAC) and counteract LUBAC activity by removing linear ('Met-1'-linked) polyubiquitin chains from substrate proteins
- The gumby–LUBAC axis plays an important role in angiogenesis, craniofacial and neuronal development by regulating canonical Wnt signalling.