ABE1378MI
MilliporeSigma™ Rabbit anti-RAD18, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1378MI-Each-of-1 | In Stock | ₹ 37,706.63 |
ABE1378MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,706.63
GST (18%): ₹ 6,787.193
Total Price: ₹ 44,493.823
Antigen
RAD18
Classification
Polyclonal
Gene Accession No.
Q9NS91
Host Species
Rabbit
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Formulation
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
RAD18; RNF73
Immunogen
GST-tagged recombinant human RAD18 C-terminal fragment.
Quantity
100 μg
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_064550
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
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Description
- Specifically detects RAD18 in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western Blotting Human Rad18 (hRad18) is a homologue of the S
- pombe Rad18
- In yeast, Rad6 and Rad18 play a crucial role in post−replication repair functions in gap−filling of daughter strands on replication of damaged DNA
- Furthermore, Rad6−Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast
- In vivo , Rad18 protein forms a tight complex with Rad6 through a conserved ring−finger motif
- It has been suggested that the Rad18−Rad6 complex binds to the damaged sites by the single−stranded DNA binding property of Rad 18
- This is followed by degradation of the stalled components of DNA replication by the ubiquitin−conjugating enzyme activity of Rad6
- The human Rad18 maps on chromosome 3p24−25, the region which is often deleted in lung, breast, ovary, and testis cancers
- The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56kDa
- The human Rad18 is ubiquitously expressed in various human tissues.