MilliporeSigma™ UTX (KDM6A), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1865MI-Each-of-1 | In Stock | ₹ 38,958.86 |
ABE1865MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,958.86
GST (18%): ₹ 7,012.595
Total Price: ₹ 45,971.455
Antigen
UTX (KDM6A)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KDM6A, KABUK2, UTX
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antibody detected the expected UTX target band in wild-type, but not Utx-knockout murine ESC nuclear extract (Faralli, H., et al. (2016). J. Clin. Invest. 126(4):1555-1565).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O15550
Immunogen
His-tagged recombinant fragment within the central region of human UTX (Seenundun, S., et al. (2010). EMBO J. 29(8):1401-1411).
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_066963
Target Species
Human
Related Products
Description
- Lysine-specific demethylase 6A (UniProt O15550; also known as Histone demethylase UTX, KDM6A, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) is encoded by the KDM6A (also known as KABUK2, UTX) gene (Gene ID 7403) in human
- KDM6A specifically demethylates Lys-27 of histone H3 and plays a central role in histone code
- It is shown to demethylate trimethylated and dimethylated, but not monomethylated H3 Lys-27
- KDM6A plays a vital role in regulation of posterior development, by regulating HOX gene expression
- KDM6A also plays a potential role in regulating brown adipocyte thermogenic program
- It is up-regulated during brown adipocyte differentiation and by cold exposure in both brown and white adipose tissue in mice, indicating its potential role in thermogenesis
- Inactivation of KDM6A down-regulates brown fat specific gene expression
- Mutations in KDM6A gene are a causative factor in Kabuki syndrome that is characterized by congenital mental retardation, postnatal dwarfism, large prominent earlobes, a cleft or high-arched palate, scoliosis, and other abnormalities.