MilliporeSigma™ Adiponectin, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS516AF488-Each-of-1 | In Stock | ₹ 46,280.00 |
ABS516AF488 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,280.00
GST (18%): ₹ 8,330.40
Total Price: ₹ 54,610.40
Antigen
Adiponectin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Adipoq, Acdc, Acrp30
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This Alexa Fluor™ 488 conjugate was prepared from purified rabbit polyclonal antibody (Mfr. No. ABS516) that was raised against rat adiponectin collagen-like domain and validated for target band detection in both rat and mouse serum samples by Western blotting. Human and Rat adiponectins share 82% sequence identity in the collagen-like domain.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Immunofluorescence
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody conjugate in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene Accession No.
Q8K3R4
Immunogen
GST-tagged recombinant rat adiponectin collagen-like domain.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_653345
Target Species
Mouse
Form
Purified
Related Products
Description
- Adiponectin (UniProt Q8K3R4; also known as 30kDa adipocyte complement-related protein, ACRP30, Adipocyte complement-related 30kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the Adipoq (also known as Acdc, Acrp30) gene (Gene ID 246253) in rat
- Adipokines are adipose tissue-secreted factors involved in vascular function and metabolic disease
- While most adipokines are proinflammatory and directly responsible for the development of the chronic inflammatory state in obesity, adiponectin is an adipokine with anti-inflammatory and insulin-sensitizing properties
- Adiponectin mediates it biological activity via adiponection receptor protein 1 and 2 (AdipoR1 and AdipoR2)
- Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively
- Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum adiponectin
- Likewise, adiponectin overexpression is reported to alleviate metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity
- Aadiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction
- Adiponectin is produced with a signal peptide sequence (a.a
- 1-18 in human and rat sequence; a.a
- 1-17 in mouse), which is removed postranslationally to yield the mature protein with a collagen-like domain (a.a
- 42-107 in human and rat, a.a
- 45-110 in mouse) and a C1q domain (a.a
- 108-244 in human and rat, a.a
- 111-247 in mouse).