BDB557194
CD271 Mouse anti-Human, Unlabeled, Clone: C40-1457, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB557194-Each-of-1 | In Stock | ₹ 14,596.00 |
BDB557194 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 14,596.00
GST (18%): ₹ 2,627.28
Total Price: ₹ 17,223.28
Antigen
CD271
Classification
Monoclonal
Concentration
0.5mg/mL
Description
NGFR; NTR; p75NTR; p75 ICD; TNFRSF16; TNR16; LNGFR
Host Species
Mouse
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
C40-1457
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
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Description
- The C40-1457 monoclonal antibody specifically binds to CD271, the nerve growth factor receptor (NGFR)
- CD271 is a transmembrane 75 kDa protein that has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves
- It is also expressed by cells in some epithelial, mesenchymal and lymphoid tissues
- NGFR is the receptor for nerve growth factor (NGF), apolypeptide that is essential for normal development of the nervous system
- NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of peripheral neurons
- NGF binds to two distinctive surface receptors expressed by target cells, the p140-TrkA (NTRK1) and the p75 NGFR
- High affinity binding of NGF requires that both receptor molecules be expressed
- NGFR has been found on human and rat lymphocytes
- A subset of lymphoid cells in the spleen, lymph nodes, and follicular dentritic cells in germinal centers of reactive lymph nodes were found to express CD271
- It has been reported that NGFR interaction with its ligand, NGF, may play a role in immunoregulation
- NGF may function as a B-cell growth factor.