BDB560414
Foxp3 Rat anti-Mouse, PE, Clone: MF23, BD
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB560414-Each-of-1 | In Stock | ₹ 17,693.20 |
BDB560414 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,693.20
GST (18%): ₹ 3,184.776
Total Price: ₹ 20,877.976
Antigen
Foxp3
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse Foxp3 Recombinant Protein
Quantity
25 μg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2b
Applications
Flow Cytometry
Clone
MF23
Conjugate
PE
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- Foxp3 is a 50-55kDa protein also known as Forkhead box P3, JM2, or IPEX
- It is a member of the forkhead or winged helix family of transcription factors and is specifically expressed by T regulatory (Treg) cells
- Foxp3 has been reported to be a key regulatory protein for Treg cell development and function
- Ectopic expression of Foxp3 in conventional T cells is sufficient to induce suppressive activity, repress the production of cytokines such as IL2 and IFN-γ, and upregulate Treg cell-associated molecules such as CD25, CTLA4 and GITR
- It has been found that the mutation of Foxp3 is responsible for “scurfy” mice
- When overexpressed, Foxp3 leads to poor T cell proliferation and activation
- Monoclonal antibody MF23 reacts with mouse Foxp3
- Immunoblotting with MF23 antibody has confirmed it recognizes an epitope between 1-87 amino acids in the N-terminal domain
- Host Species: Rat Clone: MF23 Isotype: IgG2b Species Reactivity: Mouse Immunogen: Mouse Foxp3 Recombinant Protein Intracellular Staining