CD80 Mouse anti-Human, BUV395, Clone: L307.4, BD

Description

• The L307 monoclonal antibody specifically binds to B7/BB1, a 60 kDa transmembrane glycoprotein that was clustered as CD80 in the Fifth International Workshop on Human Leukocyte Differentiation Antigens
• CD80, a member of the Ig supergene family, is expressed on activated B cells, T cells, macrophages, and dendritic cells
• It is the ligand for two molecules expressed on T cells, CD28 and CD152 (CTLA-4)
• CD80 is also expressed on activated CD4-positive and CD8-positive T cells, appearing late after activation suggesting that activated T cells may be capable of autocrine costimulation via the CD28 activation pathway
• The binding of CD28 by anti-CD28 or by CD80 results in T-cell activation and a signal for IL-2 production
• The antibody was conjugated to BD Horizon BUV395 which has been exclusively developed by BD Biosciences as an optimal dye for use on a 355nm laser equipped instrument
• With an Ex Max at 348nm and an Em Max at 395nm, this dye has virtually no spillover into any other detector
• BD Horizon BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.