Complement C5b Monoclonal Antibody (aE11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | DIA0110102-Each-of-1 | In Stock | ₹ 1,12,585.00 |
DIA0110102 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,12,585.00
GST (18%): ₹ 20,265.30
Total Price: ₹ 1,32,850.30
Antigen
Complement C5b
Classification
Monoclonal
Concentration
1.04 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P01031, P01032
Gene Symbols
C5
Immunogen
Purified C5b-9.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Equine, Human, Non-human Primate, Porcine
Product Type
Antibody
Isotype
IgG2a κ
Applications
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone
aE11
Conjugate
Unconjugated
Gene
C5
Gene Alias
anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5; C5a; C5a anaphylatoxin; C5b; C5D; CHE1; complement C5; Complement C5 alpha chain; Complement C5 alpha' chain; Complement C5 beta chain; complement C5a anaphylatoxin; complement component 5; complement component C5; CPAMD4; ECLZB; FLJ17816; FLJ17822; MGC142298; prepro-C5
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100067655, 414437, 727
Content And Storage
4° C, store in dark
Form
Liquid
Related Products
Description
- DIA 011-01-02 binds both membrane-bound MAC and fluid-phase SC5b-9 complexes from human, porcine, baboon and equine samples
- DIA 011-01-02 has been successfully used in ELISA and IHC applications
- This antibody is not recommended for Western blotting as the epitope is destroyed during the process
- C5b-9 is also known as the TCC
- TCC consists of C5b, C6, C7, C8 and C9
- The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage
- The complex contains neoantigens that are absent from the individual native components and the monoclonal antibody DIA 011-01 is directed against a neoepitope exposed in C9 when incorporated into TCC.