Phospho-IkB alpha (Ser32) Recombinant Rabbit Monoclonal Antibody (2D6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549765-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549765 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
Phospho-IkB alpha (Ser32)
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
P25963
Gene Symbols
NFKBIA
Immunogen
A synthesized peptide derived from human Phospho-NFKBIA (S32)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunocytochemistry, Western Blot
Clone
2D6
Conjugate
Unconjugated
Gene
NFKBIA
Gene Alias
AI462015, ECI-6, ECI-6/IKBA, I kappa B-alpha, I(Kappa)B(alpha), I79_018146, IkappaB alpha, IkappaBalpha, I-kappaBalpha, I-kappa-B-alpha, Ikba, IKBalpha, IKB-alpha, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha, MAD3, MAD-3, Major histocompatibility complex enhancer-binding protein MAD3, NF kappa B inhibitor alpha, NF-kappaB inhibitor alpha, NF-kappa-B inhibitor alpha, NFKB inhibitor alpha, NFKBI, Nfkbia, nuclear factor of kappa light chain gene enhancer in B-cells, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha, nuclear factor of kappa light polyp gene enhancer in B-cell 1, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, Rel-associated pp40, REL-associated protein pp40, RL/IF-1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
4792
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- IkB-alpha is a 40 kDa protein that functions to inhibit NF- kappaB activity
- The inhibition occurs via protein-protein interaction between I kappaB proteins and NF- kappaB dimers in the cytosol
- The interaction of I kappa B-alpha with NF- kappaB masks the nuclear localization sequence of NF- kappaB, preventing NF- kappaB translocation to the nucleus
- A variety of stimuli can activate gene expression by liberating NF- kappaB through the degradation of I kappaB alpha
- These stimuli include the proinflammatory cytokines TNF- alpha and IL-1 beta, chemokines, PMA, growth factors, LPS, UV irradiation, viral infection, as well as various chemical and physical stresses
- In humans, the gene is located on the q arm of chromosome 14
- Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB
- IkB kinase alpha (IKK alpha), previously designated CHUK, interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation Serines 32 and 36
- IKK alpha appears to be critical for NFkB activation in response to proinflammatory cytokines
- Phosphorylation of IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1
- The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma, and each appear to make essential contributions to IkB phosphorylation.