IKK beta Recombinant Rabbit Monoclonal Antibody (5D12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549817-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549817 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
IKK beta
Classification
Recombinant Monoclonal
Concentration
1.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
O14920
Gene Symbols
Ikbkb
Immunogen
A synthesized peptide derived from human IKK beta
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Western Blot
Clone
5D12
Conjugate
Unconjugated
Gene
Ikbkb
Gene Alias
AI132552, AIM-1, FLJ40509, I-kappa-B kinase 2, I-kappa-B-kinase beta, Ikbkb, IKK[b], IKK2, IKK-2, IKKB, IKK-B, IKKbeta, IKK-beta, IMD15, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of kappaB kinase beta, inhibitor of nuclear factor kappa B kinase beta subunit, inhibitor of nuclear factor kappa-B kinase subunit beta, MGC131801, NFKBIKB, nuclear factor NF-kappa-B inhibitor kinase beta
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3551
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Phosphorylation of serine residues on the I-kappa-B proteins by IKK kinases, including IKBKB, marks them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex
- Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK beta) is a serine kinase that plays an essential role in the NF-kaapa-B signaling pathway which is activated by mulitple stimuli such as inflammatory cytokines, bacterial, or viral products, DNA damages, or other cellular stresses
- IKK beta acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues
- These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome
- In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis
- Mutations affecting the IKK beta gene can result in Immunodeficiency 15 (IMD15).