Phospho-FAK (Tyr397) Recombinant Rabbit Monoclonal Antibody (1B3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549785-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549785 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
Phospho-FAK (Tyr397)
Classification
Recombinant Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q05397
Gene Symbols
PTK2
Immunogen
A synthesized peptide derived from human Phospho-PTK2 (Y397)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Western Blot
Clone
1B3
Conjugate
Unconjugated
Gene
PTK2
Gene Alias
CG10023, CG10023-PA, CG10023-PB, CG10023-PC, CG10023-PD, CG10023-PF, CG10023-PG, CT28129, DFAK, DFak56, Dmel\CG10023, Dmel_CG10023, DmFAK, EC 2.7.10.2, Fadk, FADK 1, Fak, Fak1, Fak56, fak56D, FAK65D, Fak-PA, Fak-PB, Fak-PC, Fak-PD, Fak-PF, Fak-PG, FAK-related non-kinase polypeptide, focal adhesion kinase, Focal adhesion kinase 1, focal adhesion kinase homolog, focal adhesion kinase isoform FAK-Del33, focal adhesion kinase pp125FAK, focal adhesion kinase-related nonkinase, focal ashension kinase 1, FRNK, I79_019430, Kiaa4203, mKIAA4203, p125FAK, p41/p43FRNK, pFAK, pp125 PTK2, pp125FAK, PPP1R71, Protein phosphatase 1 regulatory subunit 71, protein phosphatase 1, regulatory subunit 71, protein tyrosine kinase 2, protein tyrosine kinase 2 L homeolog, protein-tyrosine kinase, protein-tyrosine kinase 2, PTK2, PTK2 protein tyrosine kinase 2, ptk2.L, tyrosine kinase, XELAEV_18032408mg, XPFAK
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5747
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling
- FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle
- FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors
- Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin
- Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase
- In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin
- In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis
- Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.