CRM1 Recombinant Rabbit Monoclonal Antibody (9F2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA549899-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA549899 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
CRM1
Classification
Recombinant Monoclonal
Concentration
1.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
O14980
Gene Symbols
XPO1
Immunogen
A synthesized peptide derived from human CRM1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin)
Clone
9F2
Conjugate
Unconjugated
Gene
XPO1
Gene Alias
AA420417, chromosome region maintenance 1 homolog, chromosome region maintenance 1 protein homolog, CRM1, emb, Exp1, exportin 1, exportin 1 (CRM1 homolog, yeast), exportin 1 (CRM1, yeast, homolog), exportin 1, CRM1 homolog, exportin 1, CRM1 homolog (yeast), exportin-1, exportin-1 (required for chromosome region maintenance), Xpo1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
7514
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs
- In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP)
- Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins
- Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor
- The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.