EBI3 Recombinant Rabbit Monoclonal Antibody (12H5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550165-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550165 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
EBI3
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q14213
Gene Symbols
EBI3
Immunogen
A synthesized peptide derived from Human EBI3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Western Blot
Clone
12H5
Conjugate
Unconjugated
Gene
EBI3
Gene Alias
cytokine receptor, EBI3, EBI-3, EBV-induced gene 3 protein, Epstein-Barr virus induced 3, Epstein-Barr virus induced gene 3, Epstein-Barr virus induced gene 3 (similar to Interleukin-27 beta chain precursor), epstein-Barr virus-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein homolog, IL-27, IL27 subunit, IL-27 subunit beta, IL27B, IL-27B, IL35 subunit, interleukin-27 subunit beta
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10148
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- EBI3 (Epstein-Barr virus Induced-3) is a secreted glycoprotein of the hematopoietin receptor family
- It plays a critical regulatory role in the induction of Th2-type immune responses and the development of Th2-mediated tissue inflammation in vivo, which may be mediated through the control of iNKT cell function
- EBI3 dimerizes with p28 and p35 subunits of IL-12 to form new proteins IL-27 and IL-35, respectively
- IL-27 is an early product of activated antigen presenting cell that is produced upon TLR ligation
- It negatively regulates Th17 cell differentiation
- EBI3 is widely expressed and its expression in dendritic cell is transcriptionally regulated by TLR signaling via MyD88 and NF-kappaB during innate immune responses preceding cytokine driven Th cell development
- EBI3 signal inhibits delayed-type hypersensitivity responses by suppressing IL-17 production and inducing IL-10 hyperproduction
- EBI3 may play a novel role in controlling tumor metastasis via lung CD8+ T cells, and its deficiency is associated with a diminished production of Th2 cytokines which are known to regulate allergic airway inflammation in asthma
- Targeted deletion of EBI3 protects mice from lung metastasis.