CD34 Recombinant Mouse Monoclonal Antibody (PDM0-12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550646-Each-of-1 | In Stock | ₹ 42,275.00 |
FEMA550646 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,275.00
GST (18%): ₹ 7,609.50
Total Price: ₹ 49,884.50
Antigen
CD34
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P28906
Gene Symbols
Cd34
Immunogen
Synthetic peptide aa 336-385/385.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Clone
PDM0-12
Conjugate
Unconjugated
Gene
Cd34
Gene Alias
(E3-independent) E2 ubiquitin-conjugating enzyme R1, AU040960, CD34, CD34 antigen, CD34 molecule, CDC34, cell division cycle 34, cell division cycle 34 homolog, cluster designation 34, cluster of differentiation antigen 34, E2 ubiquitin-conjugating enzyme R1, E2-CDC34, hematopoietic progenitor cell antigen CD34, hematopoietic progenitor cell marker CD34, Mucosialin, RP11-328D5.2, sialomucin protein, type 1 transmembrane protein, UBC3, UBCH3, UBE2R1, ubiquitin carrier protein, ubiquitin conjugating enzyme E2 R1, ubiquitin-conjugating enzyme E2 R1, Ubiquitin-conjugating enzyme E2-32 kDa complementing, ubiquitin-conjugating enzyme E2-CDC34, Ubiquitin-protein ligase R1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
947
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- Positive control: Human liver tissue, human liver carcinoma tissue, human kidney tissue, human placenta tissue
- Predicted band size: 41 kDa Subcellular Location: Membrane
- CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations
- CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible
- CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors
- CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions
- CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells
- Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components
- CD34 is thought to have a role in presenting carbohydrate ligands to selectins
- The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction
- Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.