Ataxin 1 Monoclonal Antibody (4C7B11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FERMA548596-Each-of-1 | In Stock | ₹ 43,565.50 |
FERMA548596 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,565.50
GST (18%): ₹ 7,841.79
Total Price: ₹ 51,407.29
Antigen
Ataxin 1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P54253, P54254, Q63540
Gene Symbols
ATXN1
Immunogen
Purified recombinant fragment of human ATXN1 (AA: 645-815) expressed in E. Coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
4C7B11
Conjugate
Unconjugated
Gene
ATXN1
Gene Alias
2900016G23Rik; alternative ataxin1; ataxin 1; Ataxin1; ataxin-1; Atx1; Atx-1; Atx-1-PB; Atxn1; C85907; CG4547; CG4547-PB; D6S504E; dAtx-1; Dmel\CG4547; Dmel_CG4547; ENSMUSG00000074917; Gm10786; OTTHUMP00000016065; SCA1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
20238, 25049, 6310
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG1
Related Products
Description
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord
- Clinically, ADCA has been divided into three groups: ADCA types I-III
- ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes
- ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders
- Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions
- ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein
- The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations
- The function of the ataxins is not known
- This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1)
- At least two transcript variants encoding the same protein have been found for this gene.