PSD-95 Monoclonal Antibody (7E3-1B8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1046-Each-of-1 | In Stock | ₹ 52,154.00 |
MA1046 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,154.00
GST (18%): ₹ 9,387.72
Total Price: ₹ 61,541.72
Antigen
PSD-95
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P31016, P78352, Q62108
Gene Symbols
DLG4
Immunogen
Purified recombinant rat PSD-95.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat, X. laevis
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Clone
7E3-1B8
Conjugate
Unconjugated
Gene
DLG4
Gene Alias
discs large homolog 4; discs large MAGUK scaffold protein 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlg4; Dlgh4; FLJ97752; FLJ98574; post synaptic density; postsynaptic density protein 95; post-synaptic density protein 95; PSD95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; Sap90; SAP-90; SAP90A; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
13385, 1742, 29495, 779559
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-046 detects post synaptic density 95 (PSD-95) from human, rat, xenopus laevis and mouse tissues
- MA1-046 has been successfully used in Western blot, immunofluorescence, immunocytochemistry, immunohistochemistry, flow cytometry and immunoprecipitation procedures
- By Western blot, this antibody detects an ∽95 kDa protein representing PSD-95 from rat brain extracts
- Immunofluorescence staining of PSD-95 in rat hippocampal cells with MA1-046 yields a staining pattern coincident with NMDA receptor
- In immunofluorescence staining, fixation with cold methanol is recommended
- The MA1-046 immunogen is purified recombinant rat PSD-95
- This antibody was orginally validated as part of a Thermo Scientific Cellomics High Content Screening Kit
- The antibody sold separately may have slightly different performance and may need to be further optimized for the best results
- Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum
- Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain
- PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons
- There are two principal modes of interaction between PSD-95 and other proteins
- NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif
- Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains
- Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.