Bassoon Monoclonal Antibody (SAP7F407), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA120689-Each-of-1 | In Stock | ₹ 61,855.00 |
MA120689 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 61,855.00
GST (18%): ₹ 11,133.90
Total Price: ₹ 72,988.90
Antigen
Bassoon
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1mM PMSF, 50% glycerol and no preservative
Gene Accession No.
O88737, O88778
Gene Symbols
BSN
Immunogen
Recombinant, rat bassoon fragment (residues 738-1035) expressed as a fusion protein in E.coli.
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone
SAP7F407
Conjugate
Unconjugated
Gene
BSN
Gene Alias
bassoon; bassoon (presynaptic cytomatrix protein); bassoon presynaptic cytomatrix protein; BSN; Kiaa0434; neuronal double zinc finger protein; presynaptic cytomatrix protein; protein bassoon; Zinc finger protein 231; ZNF231
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
12217, 29138
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- By Western blot, this antibody detects a ∽400 kDa band represeneting the Bassoon protein
- Additional bands between 97-400 kDa are also identified and are reported to be proteolytic degradation products of Bassoon
- Bassoon is an approximately 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle
- Bassoon does not belong to any known protein families
- It has been found in rat and mouse with sequence identity of the two proteins at 96%
- The human BASSOON gene has recently been cloned and localized
- Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains
- The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration
- Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors
- Another presynaptic protein, Piccolo was found to colocalize with Bassoon in cultured hippocampal neurons
- These observations suggested that they serve specific functions at synaptic junctions and may be involved in organization of the cytoskeleton at the site of neurotransmitter release.