CtIP Monoclonal Antibody (19E8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA123304-Each-of-1 | In Stock | ₹ 49,884.50 |
MA123304 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,884.50
GST (18%): ₹ 8,979.21
Total Price: ₹ 58,863.71
Antigen
CtIP
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 20% glycerol and no preservative; pH 7
Gene Accession No.
Q80YR6, Q99708
Gene Symbols
Rbbp8
Immunogen
Human CtIP
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG1
Applications
ChIP Assay, Immunocytochemistry, Immunoprecipitation, Proximity Ligation Assay, Western Blot
Clone
19E8
Conjugate
Unconjugated
Gene
Rbbp8
Gene Alias
9930104E21Rik; COM1; CtBP-interacting protein; CtIP; DNA endonuclease RBBP8; JWDS; RB binding protein 8, endonuclease; RBBP8; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; SCKL2; Sporulation in the absence of SPO11 protein 2 homolog
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
225182, 5932
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription
- Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor
- This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation
- Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.