Agrin Monoclonal Antibody (AGR 131), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA125500-Each-of-1 | In Stock | ₹ 52,376.50 |
MA125500 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,376.50
GST (18%): ₹ 9,427.77
Total Price: ₹ 61,804.27
Antigen
Agrin
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.1mM PMSF, 50% glycerol and no preservative; pH 7.2
Gene Accession No.
A2ASQ1, P25304
Gene Symbols
Agrn
Immunogen
Recombinant rat agrin, C-terminal construct.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Radioimmune Assays (RIA), Western Blot
Clone
AGR 131
Conjugate
Unconjugated
Gene
Agrn
Gene Alias
AGR; Agrin; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 22 kDa fragment; Agrin C-terminal 90 kDa fragment; Agrin N-terminal 110 kDa subunit; agrin proteoglycan; Agrn; C22; C90; CMS8; CMSPPD; nmf380; RP23-139J18.2
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
11603, 25592
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody detects all N1 isoforms, but fails to detect the N4 protein
- Also, the antibody will detect the X, Y, and Z splice variants
- Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation
- Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction
- Several Agrin variants have been identified which arise from alternative mRNA splicings
- Agrin splice forms having inserts at two sites in the carboxy terminus designated "ey"e and "ez"e display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly
- Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention
- Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation
- Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.