Progesterone Receptor Monoclonal Antibody (PR-AT 4.14), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1410-Each-of-1 | In Stock | ₹ 49,662.00 |
MA1410 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,662.00
GST (18%): ₹ 8,939.16
Total Price: ₹ 58,601.16
Antigen
Progesterone Receptor
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P06186, P06401, Q00175, Q63449
Gene Symbols
PGR
Immunogen
Synthetic peptide corresponding to residues G(533) L P Q V Y P P Y L N Y L R P(547) of human Progesterone Receptor.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Bovine, Human, Mouse, Non-human Primate, Rabbit, Rat
Product Type
Antibody
Isotype
IgG1
Applications
ChIP Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
PR-AT 4.14
Conjugate
Unconjugated
Gene
PGR
Gene Alias
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
100009094, 100848466, 18667, 25154, 5241
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- MA1-410 detects the progesterone receptor (PR) from human, non-human primate, bovine, rat, rabbit, and mouse tissues
- This antibody does not cross-react with androgen receptor, estrogen receptor or glucocorticoid receptor
- MA1-410 has been successfully used in Western blot, immunohistochemical and immunoprecipitation procedures
- By Western blot, this antibody detects a 94 kDa and a 120 kDa protein representing PRA and PRB, respectively from T47D whole cell lysate
- MA1-410 performs better by western blot using BSA as the blocking agent and in antibody diluent
- The MA1-410 immunogen is a synthetic peptide corresponding to the binding domain residues G(533) L P Q V Y P P Y L N Y L R P(547) of human Progesterone Receptor
- MA1-410 can be used with blocking peptide PEP-016
- The progesterone receptor (PR) is a member of the steroid family of nuclear receptors
- The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy
- PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites
- PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation
- PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus
- This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity
- In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins
- Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription
- A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.