Progesterone Receptor Monoclonal Antibody (alpha PR-22), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MA1412-Each-of-1 | In Stock | ₹ 46,235.50 |
MA1412 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,235.50
GST (18%): ₹ 8,322.39
Total Price: ₹ 54,557.89
Antigen
Progesterone Receptor
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
P06401, P07812
Gene Symbols
PGR
Immunogen
Progesterone receptor purified from chick oviduct cytosol.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Chicken, Human, Reptile
Product Type
Antibody
Isotype
IgG2b
Applications
Gel Shift, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
alpha PR-22
Conjugate
Unconjugated
Gene
PGR
Gene Alias
9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
396198, 5241
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Lyophilized
Related Products
Description
- MA1-412 detects the A and B forms of progesterone receptor from chicken and some species of turtles
- This antibody does not cross-react with estrogen receptor or glucocorticoid receptor
- MA1-412 has been successfully used in Western blot and immunoprecipitation procedures
- By Western blot, this antibody detects a 78 kDa protein representing the A form and a 110 kDa protein representing the B form of PR
- The proportion of receptor bound by this product is significantly greater than catalog number MA1-411 due to the binding of both the A and B form of PR
- Protein A can effectively be used with this product in immunoprecipitation experiments
- MA1-412 detects the A and B forms of progesterone receptor from human, chicken and some species of turtles
- This antibody does not cross-react with estrogen receptor or glucocorticoid receptor
- The MA1-412 immunogen is progesterone receptor purified from chick oviduct cytosol
- Reconstitute with PBS
- The progesterone receptor (PR) is a member of the steroid family of nuclear receptors
- The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy
- PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites
- PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation
- PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus
- This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity
- In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins
- Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription
- A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.