ADORA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1041A-Each-of-1 | In Stock | ₹ 47,659.50 |
PA1041A - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,659.50
GST (18%): ₹ 8,578.71
Total Price: ₹ 56,238.21
Antigen
ADORA1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ADORA1
Gene Alias
A1AR; A1-AR; A1R; AA1R; adenosine A1 receptor; adenosine A1 receptor variant 1; adenosine A1 receptor variant 2; adenosine receptor A1; ADO-A1 receptor; ADORA1; AI848715; AR; BB176431; RDC7; Ri
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
134, 29290
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P25099, P30542
Gene Symbols
ADORA1
Immunogen
Synthetic peptide corresponding to residues C(309) Q P K P P I D E D L P E E K A E D(326) of rat Adenosine Receptor A1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-041A detects adenosine receptor A1 (A1AR) in rat tissues
- This antibody does not detect other AR subtypes
- Previous lots of this antibody have been used in human and bovine samples
- PA1-041A has been successfully used in Immunohistochemistry (paraffin) and Western blot procedures
- By Western blot, this antibody detects an ∽37 kDa protein in rat brain representing A1AR
- The PA1-041A immunogen is a synthetic peptide corresponding to residues C(309) Q P K P P I D E D L P E E K A E D(326) of rat Adenosine Receptor A1
- Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily
- Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3)
- Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission
- The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro
- In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores
- Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system
- A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release
- In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake
- Other tissues also express A1AR including kidney and testis.