MABC289MI
MilliporeSigma™ Mouse anti-FYVE (Alfy domain), Clone: 5B11.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC289MI-Each-of-1 | In Stock | ₹ 41,563.00 |
MABC289MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,563.00
GST (18%): ₹ 7,481.34
Total Price: ₹ 49,044.34
Antigen
FYVE (Alfy domain)
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
WDFY3; KIAA0993
Immunogen
GST-tagged recombinant protein corresponding to human FYVE (Alfy domain).
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_055806
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
5B11.1
Gene Accession No.
Q8IZQ1
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
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Description
- Specifically detects FYVE (Alfy domain) clone: 5B11.1 in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western Blotting Phosphatidylinositol-3-phosphate [PtdIns(3)P] regulates endocytic and autophagic membrane traffic
- PtdIns(3)P-binding proteins, many of which contain FYVE zinc-finger domains play important roles in the metabolism of PtdIns(3)P
- The FYVE-protein Alfy, is a large, scaffolding, multi-domain, PtdIns(3)P binding protein that is implicated in autophagy trafficking
- Alfy is widely expressed and localizes to the nuclear membranes during normal cell health but relocalizes to autophagic membranes and ubiquitin containing aggregates during cellular stress
- Alfy is also a LC3 binding protein and binds GABARAPs too
- Binding of Alfy to GABARAP is indispensable for its recruitment to LC3B-positive structures and thus, for the clearance of certain p62 structures by autophagy
- Latest research indicates that Alfy is also important in regulating autophagy's role in various diseases including rheumatoid arthritis and neurological diseases.