MABE1044MI
MilliporeSigma™ anti-PARP10/ARTD10 Clone: 5H11,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1044MI-Each-of-1 | In Stock | ₹ 36,846.00 |
MABE1044MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,846.00
GST (18%): ₹ 6,632.28
Total Price: ₹ 43,478.28
Antigen
PARP10/ARTD10
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q53GL7
Host Species
Rat
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Western Blot
Clone
5H11
Formulation
Purified rat monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
PARP10
Immunogen
GST-tagged recombinant protein corresponding to the Glycine-rich region of human PARP10/ARTD10.
Quantity
100 μg
Research Discipline
Epigenetics, Nuclear Function
Gene ID (Entrez)
NP_116178
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Related Products
Description
- Specifically detects PARP10/ARTD10 Clone: 5H11 in Human samples, and it is validated for Immunocytochemistry, Western Blotting Poly [ADP-ribose] polymerase 10 (EC 2.4.2.30; UniProt Q53GL7; also known as ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, PARP-10) is encoded by the PARP10 gene (Gene ID 84875) in human
- The ARTD/PARP family adenosine diphosphate (ADP)-ribosyltransferases share a conserved catalytic domain
- They can be divided into three classes depending on their catalytic activity
- The first class members can generate and modify their substrates with polymers of ADP-ribose (PAR), the second class consists of mono-ADP-ribosyltransferases, while the third class members possess no catalytic activity
- ARTD10 (PARP10), originally identified as a MYC-interacting protein is the first recognized member of the second class of ARTD enzymes that target substrates for mono-ADP-ribose (mADPr) modification
- ARTD10 is the only ARTD family member that contains two ubiquitin-interaction motifs (UIMs), which mediate interaction with polyubiquitin (pUb) chains with Lys63 (K63) linkage
- ARTD10 is reported to function as a negative regulator against NF-κB-dependent gene activation by targeting NEMO for mono-ADP-ribosylation and by preventing NEMO ubiquitination with K63-pUb chains.