MilliporeSigma™ IFIT5, Mouse, Unlabeled, Clone: 10A12.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF1083MI-Each-of-1 | In Stock | ₹ 40,228.00 |
MABF1083MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,228.00
GST (18%): ₹ 7,241.04
Total Price: ₹ 47,469.04
Antigen
IFIT5
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q13325
Immunogen
GST-tagged recombinant human IFIT5 fragment encompassing TPR repeats 6 and 8.
Quantity
100 μL
Research Discipline
Inflammation & Immunology
Gene ID (Entrez)
NP_036552
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
10A12.1
Conjugate
Unconjugated
Gene
IFIT5, ISG58, RI58
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 10A12.1 epitope lies within region encompassing TPR repeats 6 and 8 present in both spliced isoforms of human IFIT5 reported by UniProt (Q13325).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Interferon-induced protein with tetratricopeptide repeats 5 (UniProt Q13325; also known as IFIT-5, Interferon-induced 58kDa protein, P58, Retinoic acid- and interferon-inducible 58kDa protein) is encoded by the IFIT5 (also known as ISG58, RI58) gene (Gene ID 24138) in human
- IFIT1, IFIT2, IFIT3, and IFIT5 constitute the family of interferon-stimulated genes (ISGs) that are induced in response to virus infection, stimulation by interferons (IFNs) or double-stranded RNA (dsRNA)
- The protiens encoded by IFIT1 and IFIT2 are called ISG56 (p56) and ISG54 (p54) in both human and murine species, while the murine IFIT3 (ISG49 or p49) is of a different size than its human counterpart (ISG60 or p60) and no known murine IFIT5 analog exists
- IFIT family proteins restrict virus replication by various means
- IFIT1 is known to disrupt complex formation between eIF3 and HCV RNA and inhibit HPV E1 helicase
- IFIT3 is shown to enhance TBK1 and MAVS interation to potentiate antiviral response
- IFIT5 is reported to facilitate the interaction between I B kinase (IKK) and TGF- -activated kinase 1 (TAK1) by binding both proteins, resulting in enhanced NF- B activation as a reuslt of increased IKK phosphorylation and activation
- In addition, both IFIT1 and IFIT5 are shown to recognize viral RNA carrying 5 -triphosphate (PPP-RNA)
- Human IFIT5 contains eight tetratricopeptide repeat (TPR) helix-turn-helix motifs (a.a
- 51-84, 94-127, 138-173, 181-214, 249-282, 338-371, 376-410, 435-468), with a.a
- 254-260 within TPR repeat 5 mediating PPP-RNA interaction.