MilliporeSigma™ Serotonin Receptor 1B, Mouse, Unlabeled, Clone: 1C2.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1539MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABN1539MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
Serotonin Receptor 1B
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P28222
Immunogen
GST-tagged recombinant fragment corresponding to the thrid cytoplasmic domain of human serotonin receptor 1B.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_000854
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1C2.1
Conjugate
Unconjugated
Gene
HTR1B, HTR1DB
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1C2.1 targets an epitope within the third cytoplasmic domain of human, mouse, and rat serotonin receptor 1B.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
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Description
- 5-hydroxytryptamine receptor 1B (UniProt P28222; also known as 5-HT-1B, 5-HT-1D-beta, 5-HT1B, S12, Serotonin 1D beta receptor, Serotonin receptor 1B) is encoded by the HTR1B (also known as HTR1DB) gene (Gene ID 3351) in human
- The 5-HT receptors are grouped according to their antagonist susceptibilities and their affinities for 5-HT
- The 5-HT1 receptors are a subfamily of 5-HT receptors that were originally classified according to their inhibition of adenylyl cyclase, degree of sequence similarity and their overlapping pharmacological specificities
- The subfamily has five different receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F that can couple to Gi/Go and mediate inhibitory neurotransmission
- 5HT-1B receptor belong to the family of G-protein coupled receptors that are distributed in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen
- 5-HT-1B also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide
- Ligand binding causes a conformation change in the receptor that triggers signaling via G-proteins, which modulates the activity of down-stream effectors, such as adenylate cyclase
- Signaling via 5-HT-1B inhibits adenylate cyclase activity
- 5-HT1B receptor is known to be involved in thermoregulation, respiration, appetite control, sexual behavior, and aggression
- 5-HT-1B receptor are therapeutic targets for antimigraine drugs and for treatment of bipolar disorders, autism, and anti-aggressive agents.