MilliporeSigma™ INK4b (p15), Mouse, Unlabeled, Clone: GF10 (10C7A6),
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1664MI-Each-of-1 | In Stock | ₹ 40,292.08 |
MABE1664MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
INK4b (p15)
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Mouse monoclonal IgG1κ hybridoma culture supernatant with 0.05% Sodium Azide.
Gene Accession No.
P42772
Immunogen
Recombinant full-length human INK4b (p15).
Quantity
100 μL
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_004927
Target Species
Human
Form
Culture Supernatant
Applications
Western Blot
Clone
GF10 (10C7A6)
Conjugate
Unconjugated
Gene
CDKN2B, MTS2
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone GF10 (10C7A6), Mfr. No. MABE1664 and clone GF7 (7CIG4), Mfr. No. 05-430 correspond to two independent clones originated from the same mouse host. Clone GF10 (10C7A6) is recommended as an alternative to clone GF7 (7CIG4), however these two clones are expected to recognize different epitopes, exhibit different target-binding affinity and species cross-reactivity. Cross-reactivity of clone GF10 (10C7A6) toward spliced isoform 2 (p10; UniProt P42772-2) has not been confirmed.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG1 κ
Related Products
Description
- Cyclin-dependent kinase 4 inhibitor B (UniProt P42772; also known as MTS-2, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b, p15INK4B) is encoded by the CDKN2B (also known as MTS2) gene (Gene ID 1030) in human
- The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation
- INK4a and INK4b (encoded by the CDKN2A and CDKN2B gene, respectively) constitute the INK4 subfamily of CDKis
- INK4a and INK4b are induced by oncogenic Ras and are involved in cell cycle G1 arrest and cellular senescence
- Inactivation of CDKN2A and CDKN2B are found in a wide variety of human malignancies and murine tumor models.