MilliporeSigma™ PML Isoform II, Mouse, Unlabeled, Clone: 1A8.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE175MI-Each-of-1 | In Stock | ₹ 32,629.18 |
MABE175MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,629.18
GST (18%): ₹ 5,873.252
Total Price: ₹ 38,502.432
Antigen
PML Isoform II
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P29590-8
Immunogen
KLH-conjugated linear peptide corresponding to a C-terminal sequence of human PML Isoform II.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_150242
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1A8.1
Conjugate
Unconjugated
Gene
PML, MYL, PP8675, RNF71, TRIM19
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1A8.1 was raised against an C-terminal region sequence unique to PML isoform II (PML-2), but not present in the other 11 PML spliced isoforms reported by UniProt (P29590).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Protein PML (UniProt P29590; also known as Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19) is encoded by the PML (also known as MYL, PP8675, RNF71, TRIM19) gene (Gene ID 5371) in human
- The human PML gene/protein adopted its name when it was originally discovered as an RARα fusion protein caused by chromosomal translocation in acute promyelocytic leukemia (APL) patients
- In normal cells, the PML protein interacts with multiple protein partners in the nucleus to form PML nuclear bodies (PML-NBs) that mediate a variety of cellular functions including senescence, apoptosis, protein degradation, telemere stasbility, and antiviral defense
- At least 12 PML isoforms are generated by alternative splicings, including six nuclear isoforms (PML-I to PML-VI) and the cytoplasmic isoform PML-VII (a.k.a
- PML-VIIB), other spliced isoforms wihtout exon 6-coding sequence (a.a
- 467-552) are likewise expected to be cytoplasmic due to the abscence of nuclear localization signal (NLS) encoded by exon 6
- All isoforms share the same N-terminal region (a.a
- 1-419) containing the RBCC/tripartite motif and may have related functions due to their common functional RBCC/TRIM domain, while increasing evidences also suggest that each PML isoform possesses distinct functions mediated by its specific C-terminal sequence
- Isoform PML-1 (a.k.a
- PML-I, TRIM19alpha; UniProt P29590-1) and PML-2 (a.k.a
- PML-II or TRIM19kappa; UniProt P29590-8) share the same N-terminal 570-a.a
- sequence (encoded by exons 1 to 7a), however PML-1 derives its remaining C-terminal sequence (a.a
- 571-882) from exons 8a and 9, while PML-II derives its (a.a
- 571-829) from exon 7b with a different reading frame as that of PML-V.